SubtiBank SubtiBank
rsbR [2017-02-27 15:02:04]
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rsbR [2017-02-27 15:02:04]

locus
BSU04670
pI
4.00
mw
30.00 kDa
protein length
274 aa Sequence Blast
gene length
822 bp Sequence Blast
function
control of SigB activity
product
activator of RsbT kinase activity, stressosome sensor protein
essential
no
synonyms
ycxR, rsbRA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.6|Phosphorylation on a Thr residue]

    • Gene

    Coordinates on the chromosome (coding sequence)
    519,408 -> 520,232

    The protein

    Catalyzed reaction/ biological activity

  • positive regulator of [protein|6C5397BA5839E4DB25B370B39B6DA702147DA8B7|YtvA]-dependent light activation of the [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB] stress response [Pubmed|22287516]
  • phosphorylated [protein|621357D1FB6AC1B0499732EFE226F982B26CE34E|RsbR] activates the kinase activity of [protein|ADC52A22950736A0435AEEEC43F7407878786A81|RsbT] [Pubmed|23320651]

    • Paralogous protein(s)

  • [protein|F53C527995909A1CFA72C7BF919DD10EE175C6D7|RsbRB], [protein|5EEEDE60CE9E5CDAEBAB0E03AABDF1DF62F1F002|RsbRC], [protein|979D7A45EAD97C99015029400A85795061BAA367|RsbRD], [protein|6C5397BA5839E4DB25B370B39B6DA702147DA8B7|YtvA]

    • [SW|Domains]

  • RsbRA is composed of an N-terminal nonheme globin domain and a highly conserved C-terminal STAS (Sulphate Transporter and AntiSigma factor antagonist) domain. The C-terminal STAS domain is the target of the serine/threonine-specific kinase [protein|ADC52A22950736A0435AEEEC43F7407878786A81|RsbT] (see below).

    • Modification

  • phosphorylation on Thr-171 and Thr-205 by [protein|ADC52A22950736A0435AEEEC43F7407878786A81|RsbT] [Pubmed|21362065]

    • Structure

  • [PDB|2BNL] (N-terminal domain), [PDB|3VY9] (complete stressosome)
    • Expression and Regulation
    [[this]]

    Labs working on this gene/protein

  • [SW|Bill Haldenwang], San Antonio, USA
  • [SW|Chet Price], Davis, USA [http://foodscience.ucdavis.edu/price_lab/pricelab.html homepage]
  • [SW|Rick Lewis], Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/r.lewis homepage]

    • References

    Reviews

  • 19704888,16319496,20658979,23416074

    • Original Articles

  • 8002610,8682769,8682789,17726680,10781545,15583165,8824586,10329124,17158665,9179850,8808936,15312768,11244072,15342582,15378759,12950928,15466036,9179850,8955331,18832644,17726680,17218307,20019076,21602359,23320651,21362065,20935101,22287516,22609918,24599254